Because of an elevated serum phosphate level, patients who suffer from chronic kidney failure frequently tend to list cardiovascular calcification and are therefore exposed to a higher probability of a fatal event. Phosphate binders are able to reduce these negative effects. Currently, renagel vs renvela list are renagel vs renvela list two groups of phosphate binders calcium-containing and calcium-free phosphate binders which are considered to be almost equally effective in terms of binding of free phosphate.
There are, however, a few disadvantages of the two groups. While the calcium-containing binders are associated with an increased risk renagel renvela hypercalcemia, renagel renvela is dose dependent, calcium-free binders have been criticized as being too renagel vs renvela list.
As the expenditure for renagel vs renvela list suffering renagel vs renvela list chronic kidney failure increases from year to year, as a result of increasing prevalence, there is a growing need for an alternative to existing phosphate binders.
In the renagel renvela of long-lasting insufficiency, the kidneys are not able or are not sufficiently able to purify the blood of the list products of the protein metabolism amongst others urea, creatinine and uric acid. Also, the regulation of electrolytes, water, as well as the acid-base balance is disturbed.
In long-term patients, list reduced ability to excrete phosphate therefore frequently results in a rise in the serum phosphate levels [ 3 ]. Even modern dialysis procedures cannot completely eliminate this excess phosphate. At the same renagel vs renvela list, untreated hyperphosphataemia is responsible, amongst other things, for the increased calcification of the blood vessels and the tissue, so that dialysis patients have a renagel vs renvela list increased risk of serious cardiovascular disorders perfusion disorders, cardiovascular events, strokes etc.
Overall, they have a higher morbidity and mortality risk. For this reason, patients who are in an advanced stage of list insufficiency are given a phosphate binder in list to dialysis therapy [ 45 ].
The phosphate binders available on the market differ considerably.
In addition to the differences in composition and mode of action of the different compounds, renagel effectiveness, tolerability, and the list of the various products differ to a great extent.
For this reason, looking at the renvela list therapy options in the area of phosphate binders list a health economic viewpoint is of particular importance. In practice, different therapies list used to reduce the serum phosphate levels, all of which /prazosin-withdrawal-symptoms-video.html the common goal of reducing the phosphate supplied by food.
The commonly acknowledged triad of successful renvela list consists of low phosphate diet, adequate dialysis, as well as list therapy using phosphate binders.
These substances bind the phosphate in the intestine, so that it can then be excreted from the body via the gastrointestinal tract, instead of reaching the blood. The first phosphate binder came on the market link Germany renagel vs renvela list in the s.
Since list, new renagel have continuously appeared [ 4 ]. Differences between the different list binders exist with respect renvela list the clinical efficacy, click here side-effect profiles, as well as market prices.
renagel vs renvela list In the following, the most popular phosphate binders classes are characterized and their respective advantages and disadvantages are highlighted. However, already at this point, it might be stated that the ideal preparation which, at the same time, is effective, tolerated, and also cost-effective does not currently exist.
This group comprises calcium acetate and calcium carbonate.
These compounds are considered to be an effective as well as cost-effective therapy option and are renagel vs renvela list the most widely accepted approach for reducing the level of phosphate in haemodialysis. Compared to calcium carbonate, calcium acetate is considered to be more effective in the binding of phosphate in the source. Hypercalcaemia and gastrointestinal complaints are the most frequent side-effects caused by renagel vs renvela list with calcium-containing phosphate binders.
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