In vitro studies have shown different pharmacodynamic profiles for SSRIs, but their clinical relevance is still unknown. Paroxetine, the SSRI with the strongest serotonergic effect, also shows significant cholinergic and noradrenergic activities.
In this class of drugs, citalopram is the most selective for serotonin. We compared these two drugs and their effectiveness is paxil or celexa better for anxiety tolerability in a sample of patients with PD in a two-month treatment course. Fifty-eight patients with PD were randomly assigned to either the read more or the citalopram treatment group in a is paxil or celexa better for anxiety, randomized design.
No significant differences between the two drugs were found. Both were well tolerated, although sexual side effects and weight gain were frequent.
Anticipatory anxiety decreased significantly after the first week of treatment, and no initial worsening in the panic attacks was observed. Paroxetine and citalopram show similar anti-panic is paxil or celexa better for anxiety and a good tolerability profile. Our results support evidence that the serotonergic system plays is paxil or celexa better for anxiety significant role in the anti-panic properties of these two SSRIs.
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