Metoclopramide maximum dose for hyperemesis gravidarum

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Nausea and vomiting in pregnancy - BPJ Issue 40

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Oral and gravidarum GI prokinetic agent chemically related to procainamide; devoid of anesthetic or antiarrhythmic activity. Use should be kept to 12 weeks or less due to risk for tardive dyskinesia.

Metoclopramide Pregnancy and Breastfeeding Warnings

Metoclopramide Hydrochloride Oral Sol: Repeat every 4 to 6 hours as necessary. If required, a mg dose may be used.

Dose metoclopramide maximum dose administered in clinical practice and studies vary and include 0. Repeat doses of 0. In 3 randomized, double-blind, placebo-controlled trials, metoclopramide 0.

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In each trial, prophylactic administration of ondansetron was more effective than metoclopramide or placebo in controlling postoperative emesis. No adverse effects were reported for metoclopramide in these studies.

Per ASCO guidelines, for hyperemesis second line treatment to consider metoclopramide maximum dose for hyperemesis gravidarum those patients not responding to the usual standard antiemetic regimens. The manufacturer does not recommend metoclopramide use longer than 12 weeks in duration. Metoclopramide is significantly less effective than serotonin 5HT3 agonists at reducing emesis, and it is less tolerable.

Nausea and vomiting in pregnancy

While gravidarum a first line recommended treatment, metoclopramide is sometimes used as a second line antiemetic treatment. The manufacturer does not recommend the use of metoclopramide in pediatric patients for any use outside of small bowel intubation. Geriatric patients may respond to a dose of 5 mg. For intermittent symptoms, single doses up to 20 mg prior to the provoking situation may be metoclopramide maximum dose for hyperemesis gravidarum.

Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions.

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