Methotrexate and infections lung disease
Comment in Arthritis Lung disease.
Methotrexate has shown efficacy for the treatment of several diseases, especially rheumatoid arthritis Methotrexate and infections. Methotrexate has also been infections lung as a causative agent in disease lung disease. Patients with RA may develop pulmonary manifestations of their disease and are at methotrexate and risk of respiratory infection.
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The aim of this study was disease evaluate the relative risk RR of pulmonary disease among patients infections lung RA treated with methotrexate.
We searched here PubMed and Cochrane databases publication dates January 1, to February 1, for double-blind, randomized, lung disease trials of methotrexate versus placebo or methotrexate and comparator agents in adults with RA. Two investigators independently searched both databases, and all of the investigators reviewed the article source article studies.
We compared differences in the RR using the Mantel-Haenszel random-effects method.
Methotrexate and lung disease in rheumatoid arthritis.
A total of 22 studies with 8, participants lung disease the inclusion criteria. Methotrexate was associated with an increased risk methotrexate and infections lung disease all adverse respiratory events RR 1. Patients treated with methotrexate were not at increased risk of death due to lung disease RR 1.
A subgroup analysis of studies in which methotrexate and infections lung disease was described revealed an increased risk associated with methotrexate RR 7. Our study demonstrated a small but significant increase in the risk of lung disease in patients with RA treated with methotrexate compared with other disease-modifying antirheumatic drugs and biologic agents.
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Rheumatoid arthritis RA is a generalized disorder which can affect virtually any organ of the body. Although most patients are aware of its effects on the joints, fewer may recognise its potential for causing lung disease.
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Kelly; Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis, Rheumatology , Volume 43, Issue 2, 1 February , Pages —, https: Pneumonitis is the reason for withdrawal of MTX in 1 in patient-years compared with 1 in 35 patient-years for hepatic toxicity and 1 in 58 patient-years for neutropenia [ 3 ]. There are guidelines for effective monitoring of the hepatic and haematological toxicity of MTX [ 4 , 5 ].
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