Endogenous cholesterol synthesis is cyclical in nature with why should i take my lipitor at night greatest production during fasting states.

To maximize the effects of statins with a short half-life, fluvastatin, lovastatin, and simvastatin should be dosed at bedtime allowing the greatest drug link to be present during peak endogenous cholesterol synthesis. Why should i take my lipitor at night long half-life of atorvastatin, pitavastatin, pravastatin, and rosuvastatin allows for flexibility in administration time.

Why Should You Take Statins at Night?

Hydroxymethylglutaryl coenzyme A HMG-CoA reductase inhibitors, more commonly known as statins, are recommended as first-line agents in the reduction of low-density lipoprotein cholesterol LDL-C. There is known morbidity and mortality benefit associated why should i take my lipitor at night LDL-C reduction from statin therapy; therefore, it is vital that patients take the medication in a way that provides the greatest effect.

Although some cholesterol comes from dietary intake, a significant amount is produced endogenously. It was previously hypothesized that human cholesterol production may be cyclical in nature mimicking the confirmed pattern of cholesterol why should i take my lipitor at night in animals.

Human trials then confirmed the fluctuation in cholesterol synthesis, noting the greatest cholesterol production from the liver during fasting states.

Can I Take My Cholesterol Medication In The Morning, Instead Of At Night? - ABC News

The apparent circadian rhythm of cholesterol production sparked the recommendation that statins be dosed at bedtime to provide the greatest medication concentration when endogenous cholesterol production is the highest. Investigation of pharmacokinetic properties of individual statins disproved the need for all agents to be dosed at bedtime. Simvastatin, fluvastatin, and lovastatin have a short elimination half-life compared to other drugs within the class.

Agents with significantly shorter elimination half-lives require bedtime dosing to maximize efficacy - allowing the greatest statin why should i take my lipitor at night to be present while endogenous cholesterol synthesis is the highest.

Effects of morning versus evening administration of atorvastatin in patients with hyperlipidemia.

Alternatively, the longer half-lives of rosuvastatin, atorvastatin, pitavastatin, and pravastatin allow these agents to maintain a therapeutic drug concentration over a hour period and allow alternate administration times. Even if properly counseled to take statins with a shorter how does citalopram work do at bedtime, some patients do not comply which may result in decreased efficacy. Agents with longer half-lives allow for greater flexibility in administration time, which may why should i take my lipitor at night compliance and ultimately result in greater LDL-C reduction and ability to achieve cholesterol goals.

About Us Disclaimer Contact Us. Please enter text to search. The elimination half-lives of statins determine if an agent should be dosed at bedtime. Explanation Hydroxymethylglutaryl coenzyme A HMG-CoA reductase inhibitors, more commonly known as statins, are recommended as first-line agents in the reduction of low-density lipoprotein cholesterol LDL-C.

Does lipitor work better if you take it at night?

Why should i take my lipitor at night panel on the detection, evaluation, and treatment of high blood cholesterol in adults: Why should i take my lipitor at night R, Cohen H.

Evidence for diurnal periodicity in human cholesterol synthesis. Principles of Medical Pharmacology.

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The effects of morning versus evening administration of atorvastatin in hyperlipidemic patients were studied. Patients whose care was managed by a teaching hospital run by the Department of Veterans Affairs who were prescribed atorvastatin calcium 40 mg p. Patients were excluded if they had diseases or conditions or took medication known to affect serum lipoprotein levels, as were patients who consumed more than three alcoholic drinks per day and those who could not verify the time of atorvastatin administration.

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I have been told to take my cholesterol medication at night. Can I take it together with my other medications in the morning, instead? So, your doctor says you must take these cholesterol medicines at night.

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Statins are prescription medications that help to lower cholesterol. They specifically target low-density lipoprotein LDL cholesterol.