Available forms Available by prescription only Dividose tablets: Initially, mg daily trazodone 150 divided doses, which can be increased by 50 mg daily q 3 to 4 days. Average dose ranges here mg trazodone 150 90 mg mg daily.
Maximum dose is mg daily in outpatients; mg daily in hospitalized patients. Trazodone is thought to exert its antidepressant trazodone 150 by inhibiting reuptake of norepinephrine and serotonin in CNS nerve terminals presynaptic neuronswhich enhances activity of these neurotransmitters in the synaptic cleft.
Trazodone shares some properties with tricyclic antidepressants: It has antihistaminic, alpha-blocking, analgesic, trazodone 150 sedative effects as well as relaxant effects on skeletal muscle. Unlike tricyclic antidepressants, however, trazodone counteracts the pressor effects of norepinephrine, has limited effects on the CV system, and, in particular, has no direct quinidine-like effects on cardiac tissue; it also causes relatively fewer anticholinergic effects.
Trazodone has been used in patients with alcohol dependence to trazodone 150 90 mg tremors and to trazodone 150 90 mg anxiety and depression. Adverse reactions are somewhat dose-related; risk increases with higher dosages.
Well absorbed from GI tract. Widely distributed throughout the body.
trazodone 150 Steady state plasma levels are reached in 3 to 7 days, and onset of therapeutic activity occurs in 7 days. Mostly excreted in urine; the trazodone 150 is excreted in feces via the biliary tract.
Contraindications and precautions Contraindicated during here recovery phase of MI or in patients hypersensitive to drug. Use cautiously in patients with cardiac disease and in those at risk trazodone 150 90 mg suicide. Causes additive effects of antihypertensives and Trazodone 150 90 mg trazodone 150.
Dosage adjustment may be needed. Increases serum levels of digoxin and phenytoin. Selective serotonin reuptake inhibitors: Increases risk of serotonin syndrome.
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