Vlase, Georgia Panagopoulos, Michael F. Michelis; Effectiveness of furosemide in uncontrolled hypertension in the elderly: Despite many advances in the treatment of hypertension, adequate blood 140 BP control in elderly patients continues to be a challenge.
Optimal control of BP remains 140 because of issues relating to drug dosage and proper choice lasix 1 mg 140 therapeutic agents, including questions regarding the role of diuretics. We examined the effect of diuretic treatment on BP in 12 lasix hypertensive patients whose hypertension was lasix 1 mg 140 controlled on previous drug regimens.
Many of the elderly hypertensive patients in our study had decreased PRA levels and showed significant reductions in BP after furosemide administration. Am J Lasix 1 mg 140 ; The serious cardiovascular here of both diastolic and 140 hypertension in elderly 140 have been well documented. Several investigators have noted that levels of plasma renin activity PRA tend to decrease with age.
Click to see more present study focused on lasix 1 mg 140 patients with hypertension that was poorly responsive to a prior multiple drug regimen.
The study lasix 1 mg 140 designed to evaluate the hypothesis that BP, after lasix addition of a potent diuretic agent such as furosemide, could be significantly lowered, and that such changes might relate to pre- and postdiuretic measurements of both PRA and ANP. Patients were randomly referred from an outpatient medical 140 c are clinic.
Informed consent was obtained after approval lasix 1 mg 140 the study protocol by our Institutional Research Review Committee.
Twelve patients fitting click here criteria were enrolled, and furosemide was added to their antihypertensive regimen. Of the 12 patients referred, 11 were on no diuretic therapy, whereas one patient received hydrochlorothiazide, which was discontinued before enrollment. Furosemide was selected because it was believed to be a potent diuretic agent lasix 1 mg 140 appropriate for these elderly patients who could be expected to have decreased here clearances.
At the first visit, clinical and demographic data including age, sex, body weight, sitting and standing BP, heart lasix 1 mg 140, and medications lasix were recorded.
Baseline laboratory data including standard lasix 1 mg 140 chemistries, as well lasix 1 mg 140 uric acid, lasix 1 mg 140, magnesium, total lasix 1 mg 140 140, and hormonal data PRA, serum aldosterone [SA], and ANP levelsas well as a h urine collection for creatinine, protein, and sodium excretion, were obtained.
If no improvement in BP was noted at the first interim visit, the furosemide dose was increased to 20 mg twice daily and then increased further at subsequent visits by increments of 20 to 40 mg until a satisfactory response was obtained. Although most patients required the addition of only one dose of furosemide, a few patients required two or three dose increases to obtain an adequate BP response. Thereafter, patients albendazole dosage 5mg seen for a final lasix 1 mg 140. Potassium supplementation lasix 1 mg 140 used as necessary in patients on higher furosemide doses.
Goal BP values were designated to be mm Hg systolic and 80 mm Hg diastolic. The clinical, laboratory, and hormonal data were /zetia-pill-319.html at each interim visit and at the final visit. Blood pressure was measured sitting and lasix 1 mg 140 using a mercury sphygmomanometer, and the mean of triplicate values were recorded.
The following statistical methods were used.
To evaluate the changes in SBP, DBP, and MAP from baseline before furosemide administrationto the 140 and final lasix after furosemidewe used repeated measures analysis of variance.
2018 ©