Hoodia gordonii test mg

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Antidepressant-like effect of Hoodia gordonii in a forced swimming test in hoodia gordonii Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite.

Recently, it test been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study hoodia gordonii test mg the possible antidepressant-like effects of acute and repeated 15 days test of H. Test analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects.

Acute administration of H.

Hoodia gordonii anti-immobility effect of H. A significant increase in 5-HT levels in the striatum was detected after acute administration, while 5-HT, norepinephrine and dopamine were test hoodia gordonii test after chronic treatment. Results indicated that H.

Hoodia gordonii ; Antidepressant action; Monoaminergic system; Forced swimming test. Although several classes of antidepressants hoodia gordonii test mg currently being used in the treatment of this disorder, because of limited efficacy and undesirable adverse effects of test, chronic hoodia gordonii test recurrent depression is still present at high rates.

Accordingly, there is growing interest in the development of efficient and safe drugs as alternative therapeutics for the management of this mental illness 2.

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Traditional medicine from around the world relies on the use of a wide variety of medicinal plants. In recent years, an increasing number of studies test demonstrated numerous plant species test a variety of promising pharmacological properties, naltrexone suboxone 2mg film more info on the central hoodia gordonii system CNSsuch as anxiolytic and antidepressive effects 3 - 5.

Hoodia gordonii Masson Sweet ex Decne is a cactus-like succulent species from test Apocycnacaea family used traditionally among the San tribe of southern Africa to suppress appetite when away on long hunting trips 6. This traditional use was further validated in initial exploratory research when an oxypregnane glycoside P57 was proposed as the active compound related hoodia gordonii weight loss induced by administration of H. From these studies, H. However, test of the absence of scientific test for its efficacy and safety, the sale of H.

In a recent study, the administration of a test extract test H.

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Although the effects of this plant on food intake are the focus in the literature, some sympathomimetic hoodia gordonii test mg related to mood disorders could also be detected from H. However, this hypothesis has still not hoodia gordonii test mg explored. Taking this into consideration, the present study investigated a possible antidepressant-like action of acute and chronic doses of H. The FST is also an important tool for studying the neurobiological mechanisms involved in antidepressant responses.

In fact, numerous studies have hoodia gordonii test mg that the modulation of the serotonergic, noradrenergic, and dopaminergic systems in this animal model underlies the behavioral effects of several antidepressants 10 Thus, bearing in mind the monoaminergic theory of depression, the involvement of serotonergic, noradrenergic, and dopaminergic systems on the effects of H. Furthermore, with the aim of corroborating the results from these hoodia gordonii test mg, we also conducted a neurochemical analysis of brain monoamines in the animals, test high-performance liquid chromatography HPLC.

Male Swiss mice g maintained on a In test study, hoodia gordonii commercial dry purified extract of H. This product is manufactured in accordance with the requirements of the Medicines and Healthcare Products Regulatory Agency in the United Kingdom. The active ingredient content P57 is guaranteed through regular hoodia gordonii test mg performed by the company's Laboratory for Quality Control.

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Test, the material was shown to be free of microbiological contamination hoodia gordonii test mg was at a dilution of The purchase of the substance was made for research purposes. For the use of the drug in our experiments, H.

The additional drugs used test this study were: All drugs were diluted in distilled water hoodia gordonii test mg administered by the intraperitoneal ip route. Subsequently, 60 min after the last administration, animals were tested in the FST. The test was conducted using the method of Porsolt et al.

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