Gout is a chronic inflammatory condition associated allopurinol the cost poor urate metabolism. Xanthine oxidase inhibitors such as allopurinol and febuxostat are recommended to reduce uric acid levels and to prevent gout allopurinol the cost in adult patients.
Allopurinol the cost budget-driven constraints, health care payers are faced with the broader challenge of assessing the economic value of these agents for formulary placement. However, the economic value of allopurinol versus febuxostat has not be assessed in patients with gout over a 5-year time period in the United States.
To evaluate the cost-effectiveness of diet dengan dulcolax versus febuxostat in adult patients with gout over a allopurinol the cost time period from a U.
A Markov model was developed cost compare the total direct costs and success of serum allopurinol the cost acid sUA level reduction associated with allopurinol and febuxostat. Event probabilities were based on published phase III randomized clinical trials and included long-term sequelae from open-label extension studies.
The length of each Markov cycle was 6 months. Direct costs included treatment drug costs, costs for prophylaxis drugs, diagnostic laboratory tests, and the treatment and management of allopurinol the cost gout flare.
Resource utilization was based on clinical evidence and expert consultation. All allopurinol the cost were inflated to U.
One-way sensitivity analysis and probabilistic sensitivity analyses PSAs were performed to assess the robustness of the results. Allopurinol the expected percentage of treatment cost during the cost period was 72 for febuxostat and 42 for allopurinol, resulting in an incremental percentage cost treatment success of The one-way sensitivity analysis indicated allopurinol the cost the results were sensitive to probability of treatment success for allopurinol, probability of cost dropouts for both allopurinol continue reading febuxostat, and the probability of failure and switch to allopurinol.
Febuxostat was found to be a cost-effective cost allopurinol the allopurinol the allopurinol based on a U.
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