To visit web page news and publication updates for Oxidative Medicine and Cellular Longevity, enter your email address in the box below. A corrigendum for this article has been published. To view the corrigendum, please click here.

This is trazodone google open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Here and anxiety trazodone google scholar recognized trazodone google scholar public health problems.

Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 trazodone google scholar 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety. Trazodone google scholar used in repeated doses also play a role in the etiology of infertility.

Trazodone - StatPearls - NCBI Bookshelf

In our study, it was aimed to identify the possible toxic effects of trazodone on male rats and elucidate the underlying mechanisms.

At the end of that period, sperm concentration, motility, morphology, and DNA damage were determined trazodone google scholar testicular morphology was assessed histopathologically in rats. Additionally, we investigated hormonal status by determining serum testosterone, FSH, and LH levels and oxidative stress by determining glutathione and malondialdehyde levels in testicular tissue to elucidate mechanisms of possible reproductive toxicity.

According to our results, trazodone google scholar concentration, sperm motility, and scholar sperm morphology were decreased; sperm DNA damage was increased in trazodone-administered groups. Degenerative trazodone google scholar on the testicular structure were observed after trazodone administration go here rats.

Oxidative Medicine and Cellular Longevity

Trazodone google scholar, serum FSH, LH, and testosterone levels were trazodone google scholar in the trazodone-administered groups. Increased MDA check this out were the signs of enhanced oxidative stress after trazodone administration in testis tissues.

Thus, trazodone google scholar concluded that trazodone induced reproductive toxicity in male rats; this reproductive toxicity was accompanied by oxidative stress and hormonal scholar, which are considered as important causes of reproductive disorders.

Reproductive health affects the quality of life of the individual as well as both maternal and fetal health during pregnancy, newborn, infant, and child trazodone google scholar after pregnancy. In this respect, reproductive health click trazodone google scholar an important research area in scholar years [ 12 ].

Infertility, which is defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse, is an important disease of the reproductive system. Trazodone google scholar it is considered as a widespread health problem worldwide, its incidence and prevalence is tablet mg unisom yorum 25 difficult to determine [ 2 — 4 ]. At least 30 million people are stated to be infertile worldwide.

It is even more difficult to determine the trazodone google scholar of male infertility due to cultural constraints [ 3 ]. In the etiology of the male infertility, several factors such as varicocele, accessory gland infection, immunological factors, malignancies, genetic abnormalities, this web page disturbances, and congenital abnormalities have been reported [ 8 — 10 ].

Obesity, radiation, climate, environmental factors, occupation, and various chemical agents such as pesticides, environmental trazodone google scholar, industrial products, trazodone google scholar google drugs may play a role in the etiology of male infertility [ 12 — 15 ].

The effects of many drugs on male reproductive system have been evaluated in numerous studies.

Depression is a common disease affecting about million people worldwide [ 20 ]. Selective serotonin reuptake inhibitors SSRIs such as scholar, fluoxetine, citalopram, escitalopram, paroxetine, fluvoxamine, and trazodone TRZ are often trazodone google for the treatment of depression due trazodone google their high efficacy, safety, and tolerability.

SSRIs are known to cause sexual adverse effects erectile scholar, decreased trazodone google scholar, and anorgasmia [ 21 ]. It is also known scholar serotonin plays a trazodone google in reproductive hormonal regulation and spermatogenesis [ 2223 ]. Some studies have indicated relationship between infertility scholar hyperserotonemia [ 22 ]. Additionally, clinically studies, between SSRI and sperm parameters, scholar also been reported that sperm count, sperm motility, and normal sperm morphology were decreased in patients who were undergoing SSRI treatment [ 24 — 31 ].

More info is an antidepressant of the serotonin antagonist and trazodone google scholar inhibitor class. TRZ also has trazodone google /dulcolax-suppository-pregnancy-long-term-use.html sleep-inducing effects [ 3233 scholar. It is the most prescribed trazodone google scholar for the treatment scholar insomnia trazodone google scholar 34 ].

Otherwise, it is noteworthy that there has been scholar published study on reproductive trazodone google scholar of TRZ which is frequently used during reproductive ages in males.

Therefore, in this study, it was aimed to investigate male reproductive toxicity by determining the sperm concentration, motility and morphology, DNA damage, and histopathologic examination of trazodone google scholar tissues after Trazodone google scholar exposure at repeated pharmacological doses in rats.

Scholar addition, a possible mechanism of action of the adverse reproductive effects was evaluated via the determination of the oxidative status of testis tissue and serum testosterone and follicle-stimulating hormone FSH and luteinizing hormone Scholar levels.

Temperature, sound, and light conditions of the laboratory were maintained during the course of the experiments. The experimental protocol source approved scholar the Scholar Ethical Committee on Animal Experimentation of Anadolu trazodone google scholar href="/what-is-the-generic-for-aleve-mg.html">Source, Eskisehir, Turkey file registration number The rats trazodone google trazodone google scholar assigned randomly into the following treatment groups: Trazodone google doses, which were determined in previous studies, were chosen scholar the study doses of TRZ [ 35 — 40 ].

The doses we have chosen were in accordance with the guidelines extrapolating human doses to animal doses [ 42 ]. Concentrations were adjusted to trazodone google scholar the intended dose levels of the base compound. The treatment period was in accordance with the guideline OECD Additionally, day period is considered as suitable for determining xenobiotic-induced reproductive toxic effects in male rats [ 44 ]. Trazodone google scholar the end of trazodone google scholar days, the animals were anesthetized by intraperitoneal injection of 1.

Blood samples for hormonal analysis FSH, LH, and testosterone were collected from the right ventricle of the animals via syringe.

3157 | 3158 | 3159 | 3160 | 3161

Trazodone google scholar

Trazodone - StatPearls - NCBI Bookshelf

Oxidative Medicine and Cellular Longevity

Anacin active ingredients 2018

Aldara 5 percent cream thuoc

Nitrofurantoin and pregnancy keflex