The effects of seroquel qtc
Quetiapine, an atypical antipsychotic used in the intensive care unit ICU to manage delirium, has a possible adverse effect qtc corrected QT QTc interval prolongation.
The objective of this analysis was to describe the impact of quetiapine on The effects of seroquel qtc interval prolongation in critically ill patients. This was a single-center, prospective cohort analysis of ICU patients who received quetiapine between October and February qtc The major end point was the incidence of QTc prolongation qtc than 60 milliseconds above baseline during therapy.
Univariate and multivariable analyses were performed to see more variables associated with higher risk of QTc prolongation. During the study period, patients were enrolled in the analysis. QTc interval prolongation greater than 60 milliseconds occurred in the effects of seroquel qtc The median change in QTc interval was 20 the effects. There were no /cefixime-capsules-400-mg-medscape.html of TdP.
QTc prolongation was relatively uncommon among critically ill patients utilizing quetiapine. Patients receiving concomitant medications known to prolong the QTc interval seroquel be at an increased risk.
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The FDA has required the manufacturer of the secondgeneration antipsychotic quetiapine Seroquel to add a warning to the labeling saying that use of the drug should be avoided in combination with other drugs that prolong the electrocardiographic QTc interval Table 1. The warning is based only on postmarketing reports of QT-interval prolongation in patients who overdosed on the drug, had concomitant illness, or were taking other drugs known to cause electrolyte imbalances or increase the QT interval. QT prolongation can lead to torsades de pointes, a potentially fatal cardiac arrhythmia.
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QT prolongation is a rare adverse event associated with many drugs, including antipsychotics and antidepressants. The majority of cases have occurred in patients taking an offending agent with multiple identifiable risk factors for corrected QT QTc prolongation. Typical antipsychotics have been implicated in many cases of torsades de pointes and QTc prolongation.
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