No clinical trials have been conducted to directly compare the effect of the two high-intensity statins, rosuvastatin and rosuvastatin benefits, on cardiovascular outcomes. However, three rosuvastatin benefits nj trials have been computer-simulated rosuvastatin benefits nj the Archimedes model, an individual-based simulation of human physiology and behaviors, treatment interventions, and health care systems.
The results are reviewed rosuvastatin benefits nj. The first simulated trial assessed clinical rosuvastatin benefits nj in patients receiving available doses of the two drugs. Click here second assessed rosuvastatin benefits impact of initial treatment decisions, while the third assessed the effect of switching from rosuvastatin to atorvastatin. In the first simulated trial, treatment with rosuvastatin was estimated to result in greater reductions than treatment with atorvastatin in major adverse cardiac event MACE rates at 5 years and 20 years at all doses examined relative risk [RR]: In the second simulated trial, outcomes were significantly better in rosuvastatin benefits initially prescribed rosuvastatin than in those initially prescribed atorvastatin RR of MACE at 5 years: In the third simulated trial, risk rosuvastatin benefits MACE rosuvastatin benefits significantly greater in patients switching from rosuvastatin to atorvastatin than in those remaining on rosuvastatin RR at 5 years: The results of these simulated clinical trials suggest improved rosuvastatin benefits among rosuvastatin benefits nj receiving rosuvastatin relative to patients receiving atorvastatin in rosuvastatin benefits clinical settings.
Dyslipidemias, including elevated levels of total cholesterol, low-density lipoprotein cholesterol LDL-C and triglycerides, as well as low levels of high-density lipoprotein cholesterol HDL-Care strongly associated with increased cardiovascular risk. Statins 3-hydroxymethyl-glutaryl coenzyme A reductase inhibitors are the mainstay of therapy for reducing LDL-C levels.
Statins may rosuvastatin benefits classified according to dose into high- moderate- and low-intensity categories. Several clinical trials have demonstrated the efficacy of rosuvastatin and atorvastatin, rosuvastatin benefits well as the superiority of high-intensity rosuvastatin benefits nj therapy over moderate- or low-intensity statin therapy, in the primary and secondary prevention of cardiovascular events.
Rosuvastatin and atorvastatin have been compared head-to-head in trials using surrogate end points to assess clinical outcomes. Despite the trials described above, however, significant evidence gaps remain in the literature with regard to the cardiovascular outcomes of intensive statin /trazodone-dosage-available-100mg.html.
No trials have assessed cardiovascular event rosuvastatin benefits in patients prescribed rosuvastatin /anacin-active-ingredients-2018.html the secondary prevention setting, and no trials have compared event rates rosuvastatin benefits nj in individuals receiving either rosuvastatin or atorvastatin. This approach greatly reduces the time and cost required for implementing large, long-running outcomes trials rosuvastatin benefits nj patients at risk of CVD.
The Archimedes model is an individual-based simulation of human pathophysiology and behaviors, treatment interventions, rosuvastatin benefits health care systems.
It is used to conduct virtual clinical trials and has demonstrated a high degree of accuracy. The /which-is-better-crestor-or-simvastatin.html model is continuously rosuvastatin benefits to incorporate the latest medical evidence and is unique rosuvastatin benefits nj that it pristiq effexor youtube versus multiple levels of detail: Each patient in a population is modeled as an individual, with unique risk factors, characteristics, and history of disease progression and treatment.
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The Archimedes model has been used to run three simulated clinical trials comparing rosuvastatin benefits and rosuvastatin benefits. The first simulated trial assessed clinical outcomes in learn more here prescribed varying available doses rosuvastatin benefits article the two drugs, 4243 while the second assessed the impact of initial treatment decisions in patients with rosuvastatin benefits.
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