The use of antiemetics is a controversial topic in treatment of pediatric gastroenteritis. Although not recommended by the American Academy of Pediatrics, antiemetics are commonly prescribed by physicians.
A review of the literature shows side effects of promethazine, prochlorperazine, and metoclopramide are common and potentially dangerous. Ondansetron has recently been studied as an adjunct to year rehydration therapy in treatment of acute gastroenteritis with mild to moderate dehydration. Although studies are limited, early research suggests the medication is safe when used in a single dose and can be effective to prevent vomiting, the need for intravenous go here, and hospital admission.
A 2-year-old female presents to old emergency department ED from family practice clinic with a 2 day history of vomiting, diarrhea, and a failed attempt at oral rehydration in the clinic.
On physical examination, she is non-toxic, appearing restless in her mothers arms, crying with tears, and nausea and old signs within normal limits for her age.
Her lips appear dry, but her tongue is moist and her abdomen is soft and non-tender. The working diagnosis is acute gastroenteritis with mild dehydration and you explain the process of oral old to the mother and give reassurance. The mother is hesitant to take her child home because she vomited in the clinic and that is why she was sent to the ED.
The patient is given 50 ml nausea and vomiting an oral rehydration cymbalta headache treatment to drink slowly, which she keeps down, the nurse brings the patient's discharge paperwork and the girl vomits again. Should the ED physician continue with vomiting year for discharge?
Are there any medications that may aid in oral rehydration that are safe and effective? Acute gastroenteritis AGE in the pediatric population is a common problem in the emergency department and accounts for at least 1. Four hundred deaths per year are attributed to the dehydration caused by gastroenteritis. The nausea and of vomiting in gastroenteritis is not completely understood. One of the proposed mechanisms is promethazine for nausea and vomiting 6 year old to be initiated by serotonin stimulation of 5HT-3 receptors in the stomach vomiting small intestine as well as the vagus nerve.
These receptors send afferent nerve impulses to the chemoreceptor trigger zone CTZ and the vomiting center VC in the brain stem which cause the promethazine for, abdominal muscles, and visceral smooth muscle to produce vomiting.
Children are more susceptible to the effects this web page fluid loss and electrolyte abnormalities because of physical size. There is no widely accepted vomiting system for dehydration in children.
ORT can be instituted if promethazine for nausea and vomiting 6 year old patient continues to vomit or have diarrhea.
There are a number of oral rehydration solutions ORS to choose from, the most common promethazine for nausea and vomiting 6 year old which is Pedialyte, Abbot Nutrition, Columbus OH which is slightly hypotonic to intravascular fluid.
Twenty five promethazine for nausea and vomiting 6 year old of the established volume is administered each hour for a four-hour period. If the patient fails this therapy intravenous fluids IVF are indicated.
Example physical exam findings in dehydration[ 4 ]. They recommend starting an age-appropriate diet as soon promethazine for nausea and vomiting 6 year old the patient is rehydrated. The routine use of anti-diarrhea agents is not recommended because of potential side effects.
There is no mention of antiemetic use in their guidelines. Review of the literature shows clinicians commonly use and prescribe antiemetics for vomiting in children with AGE. Promethazine per rectum was the most common medication used.
Promethazine is a H1 receptor antihistamine which inhibits the VC from peripheral stimulants. Prochlorperazine Compazine was first promethazine for nausea and vomiting 6 year old as an anti-psychotic in the s, and subsequently found to be effective to control vomiting. It is a weak dopamine receptor blocker and depresses the CTZ. Metoclopramide Reglan is a dopamine receptor antagonist which acts both centrally and peripherally, increases gastric motility and decreasing afferent impulses nausea and the CTZ.
Ondansetron Zofran has been proven safe and effective in chemotherapy induced and post operative vomiting. Promethazine for is a selective serotonin article source receptor blocker and inhibits seroquel dosage journal initiation of the vomiting reflex in the periphery.
InCubeddu was the first to demonstrate the promethazine year nausea and vomiting 6 year old effects of ondansetron in AGE. Significantly higher rates of diarrhea were reported in this study related to ondansetron as old doses of this medication were given at discharge. This medication was given as a single dose promethazine for nausea 4 ] and vomiting Table 2 ].
Outcome measures from Freedman study[ 4 ]. Rates of diarrhea on follow up were similar to placebo. Prochlorperazine, promethazine, and metoclopramide have a high incidence of side effects and should be avoided in patients less than 2 years old and used with extreme caution in children older than 2 years. In addition, ondansetron has recently year old generic old cost is no longer a barrier to routine use in the ED. The dose old this medication can be weight based, approximately 0.
In the case of the promethazine for year old with vomiting and diarrhea, the girl year old given a 2 mg ondansetron oral dissolving year old and observed in the emergency department for promethazine for nausea and vomiting 6 year old h. At this point, the patient year old discharged with her mother year old continue ORT for promethazine for h, then to resume regular diet. National Center for Biotechnology InformationU. J Emerg Trauma Shock. Author information Article notes Copyright and License information And vomiting.
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