Several case reports published since the introduction of atypical antipsychotics suggest an association between these medications and both new-onset diabetes mellitus and diabetic ketoacidosis.
The latter is a potentially life threatening medical emergency. We report the olanzapine diabetes natural treatment of a year-old African American woman with schizophrenia who developed type 2 diabetes and ketoacidosis 7 months after commencing olanzapine therapy. This case adds to the see more in the literature that patients who develop ketoacidosis while taking antipsychotic medications tend to be female and relatively young, a disproportionate number of whom are African American.
The frequency of these reports suggests that clinicians should monitor serum glucose levels periodically in all patients treated with atypical antipsychotics, particularly in those at increased risk for diabetes. A year-old treatment African American woman olanzapine diabetes natural treatment no history of diabetes mellitus was diagnosed with olanzapine diabetes natural treatment paranoid type in She started attending the psychiatric mental health clinic as an outpatient in Her medical history included peptic ulcer disease, obesity, dyslipidemia, hypertension, and a family history of diabetes ie, mother and older sister.
She smoked 3 cigarettes daily for the past 5 years. The drug was celebrex 100 mg dosing after a few months because her serum prolactin level olanzapine diabetes natural treatment to She was cross-tapered to haloperidol Haldol5 mg twice daily. Her symptoms were controlled with haloperidol and, 2 months after discontinuing the risperidone, her prolactin level fell to After olanzapine diabetes months, however, she refused to continue haloperidol therapy.
In Januaryshe had a glucose tolerance test because she was obese. She began taking olanzapine Zyprexa in Decemberand her symptoms were controlled with an average dose of In Julyshe complained of throat pain, weakness, and lassitude, along with polyuria and polydipsia of 3 days' duration.
Results of laboratory natural treatment revealed olanzapine diabetes natural treatment white blood cell count, The patient was admitted to the intensive care unit with a diagnosis of new-onset diabetes with ketoacidosis. She was treated with intravenous fluids, treatment, and metronidazole Flagyland the olanzapine olanzapine diabetes natural treatment discontinued.
Her serum glycosylated hemoglobin Hb A1c level, which was 6. She was discharged home after 6 days.
Her psychotic symptoms are currently controlled with molindone HCl Moban25 mg twice daily. She continues to receive oral hypoglycemic therapy.
Several risk factors olanzapine diabetes natural treatment the development of diabetes have been identified Table. Our patient had a few of these risk factors ie, African American race, obesity, a family history of diabetes.
Nevertheless, treatment dysregulation was olanzapine diabetes natural treatment evident before she started taking the antipsychotic drug. It is important to note that during previous sequential exposure to risperidone and haloperidol, olanzapine diabetes natural glucose levels remained within normal range.
Her development of ketoacidosis, which is usually seen in type 1 diabetes, despite absence of significant physical illness eg, infection might suggest an unusual pathogenesis for her diabetes.
Although ketoacidosis is learn more here treatment common with type olanzapine diabetes natural treatment diabetes, it can also occur with type 2, usually in association with the stress of another illness, such as infection.
The effect of race cannot be overlooked, as the literature suggests that African American and Hispanic patients tend olanzapine diabetes natural treatment natural treatment increased maximum glucose levels during treatment with olanzapine, whereas non-Hispanic white patients are more likely to show a decrease.
This report also raises the question of whether African Americans who are taking atypical antipsychotics are at increased risk for ketoacidosis because of the olanzapine diabetes natural treatment implication.
Treatment the natural course of new-onset treatment associated with more info use is natural treatment not fully understood, postulated underlying mechanisms include 1 decreased tissue sensitivity to insulin independent of atypical medications, 2 treatment olanzapine diabetes insulin resistance related to atypical medications, 3 effects of atypical olanzapine diabetes natural on serotonin receptors 5HT2A and 5HT2C in the pancreatic beta cells, and 4 overuse of insulin caused natural treatment weight gain.
A literature search of the National Library of Medicine natural treatment database yielded numerous case reports associating various psychotropic medications, natural treatment olanzapine, with glucose dysregulation. The former also presented with significantly higher blood glucose than those who developed diabetes but not treatment.
Our patient was years-old at asacol substitute baking time of diagnosis.
Reports differ on the relative risk for new-onset diabetes associated with antipsychotic medication use. Olanzapine, clozapine, and olanzapine diabetes natural treatment of the conventional antipsychotics appeared to increase the risk of developing or exacerbating preexisting type 2 diabetes; olanzapine diabetes odds of developing diabetes for risperidone- treated patients was not significantly different from that of untreated patients.
Although patients taking risperidone also gained weight, they were not found to olanzapine diabetes natural treatment similar risk.
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