Nitrofurantoin pulmonary fibrosis uptodate

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We report a case link a nitrofurantoin pulmonary fibrosis uptodate admitted to the emergency department with fever and fibrosis uptodate nitrofurantoin pulmonary fibrosis uptodate Fibrosis uptodate acute respiratory failure. Nitrofurantoin is an antimicrobial drug used for treatment of uncomplicated urinary tract infections UTIs and as prophylaxis against fibrosis uptodate UTIs nitrofurantoin pulmonary. Chronic pulmonary reactions caused by nitrofurantoin include diffuse interstitial pneumonitis and pulmonary fibrosis and they are related to the total lifetime dosage.

The patient had no relevant occupational exposure, more info allergies, travel history, or previous lung disease. Auscultation of the chest revealed fine inspiratory crackles on the nitrofurantoin pulmonary fibrosis uptodate and nitrofurantoin pulmonary lung zones bilaterally. The rest of physical examination did not reveal noteworthy findings. Nitrofurantoin pulmonary fibrosis uptodate /what-is-cipro-treat.html revealed sinus tachycardia without any other abnormalities.

Laboratory results showed increased leucocytes High resolution computerized tomography HRCT scan of the chest showed bilateral inter and intralobular septal thickening mainly involving the mid and lower lung zones, centrilobular nodules bilaterally, bilateral small pleural fibrosis uptodate, and patchy ground glass opacities Fig.

Nitrofurantoin‐induced acute pulmonary toxicity

High resolution computerized tomography HRCT image of the nitrofurantoin pulmonary fibrosis uptodate. The patient was supported with supplemental oxygen. Treatment with ceftriaxone and macrolide was administered pending the results of the laboratory tests.

Nitrofurantoin was suspected to be the cause and it was discontinued fibrosis uptodate. Microscopic nitrofurantoin pulmonary fibrosis uptodate and cultures of BAL for Mycobacterium tuberculosisPneumocystis jiroveciibacteria and fungi were negative. Polymerase chain reaction of BAL for influenza and P.

Cytology test of BAL and sputum showed no malignant cells. Cultures of sputum, blood, and urine were sterile.

Nasopharyngeal swab specimen testing fibrosis uptodate influenza was negative. Urine antigens for Legionella pneumophila and S Streptococcus pneumoniae were negative.

Nitrofurantoin‐induced acute pulmonary toxicity

Serology tests for Human Immunodeficiency Virus, Hepatitis C virus, Hepatitis B virus, chlamydia, mycoplasma, rickettsia, aspergillus, and common viruses were also negative. Complement factors, quantitative immunoglobulin levels, thyroid hormones, fibrosis uptodate serum angiotensin converting enzyme were within normal limits. Rheumatoid factor and antinuclear nitrofurantoin pulmonary fibrosis uptodate were negative.

Total Immunoglobulin Ig E of the blood was increased Microscopic examination of peripheral blood smear showed eosinophilia. nitrofurantoin pulmonary

The patient was diagnosed with pulmonary toxicity due to nitrofurantoin use. In patients with this presentation and rapid deterioration, it seems necessary to rule out any possible reversible condition, such nitrofurantoin pulmonary fibrosis uptodate pulmonary infection, heart nitrofurantoin pulmonary fibrosis uptodate and pulmonary thromboembolism.

Other nitrofurantoin pulmonary fibrosis uptodate frequent etiologies should also be investigated: In this case report, all other potential causes were excluded and nitrofurantoin was diagnosed to nitrofurantoin pulmonary fibrosis uptodate nitrofurantoin pulmonary fibrosis uptodate cause. Early recognition and withdrawal of the drug is vital for the patients. Treatment with corticosteroids is not officially recommended [ 34 ].

Appropriate written informed consent was obtained for publication of this case report and accompanying images.

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