Imitrex interactions with other medications propranolol
The effect of twice-daily dosing with propranolol on the pharmacokinetics and pharmacodynamics of a single oral dose of sumatriptan was investigated in 10 healthy male subjects.
Each subject received 7 days dosing with propranolol 80 mg twice other medications propranolol plus a single dose of sumatriptan mg orally on day 7; on another separate occasion, placebo was administered for 7 days plus a single dose of sumatriptan on day 7.
There was imitrex interactions with least imitrex interactions with other medications propranolol 7 day washout interval between the two periods of dosing.
Imitrex (sumatriptan) Drug Interactions
Pulse and blood source were measured up to imitrex interactions with other medications propranolol h click dosing with sumatriptan and blood samples were taken up to 26 h post-dose. Propranolol had no significant effect on any of the derived pharmacokinetic parameters of sumatriptan.
The appropriate average parameter values in the presence of propranolol were, respectively: Cmax ng ml-1 vs ng ml-1tmax 4. Propranolol had no significant effect on the pharmacodynamics of sumatriptan, as other medications propranolol by pulse rate and blood pressure.
The results of this study would suggest that no alteration in the sumatriptan dosage will be necessary for migraine patients taking propranolol prophylactic therapy.
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Propranolol, which treats high blood pressure, irregular heart rhythms, chest pain, and other heart symptoms, is also approved by the U. Propranolol falls into the beta-blocker class of medications.
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Drugs used in the treatment of headache usually do not cause problems, even when used in combination with various other medications. However, some drugs can interact in ways that may not be beneficial. To help you when you and your practitioner design your treatment plan, this article explains common drug interactions.
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A total of drugs are known to interact with Imitrex sumatriptan. Show all medications in the database that may interact with Imitrex sumatriptan. There are 4 disease interactions with Imitrex sumatriptan which include:.
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