Medically reviewed on Jan 1, Xenical is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Xenical is also indicated to reduce the risk for weight regain after prior weight loss. Table 1 how to use orlistat 120mg er body mass index BMI according to how to use orlistat 120mg er variety of weights and heights. The BMI is calculated by dividing weight in kilograms by height in meters squared.
For example, a person who weighs lbs and is 5 ' 5 " would how to use orlistat 120mg er a BMI of The recommended dose of Xenical is one mg capsule three times a day with each main meal containing fat during or up to 1 hour after the meal.
The daily intake of fat, carbohydrate, and protein should be distributed over three main meals.
If a meal is occasionally missed or contains no fat, the dose of Xenical can be omitted. Because Xenical has been shown to reduce the absorption of some fat-soluble vitamins and how to use orlistat 120mg er, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition [see Warnings and Precautions 5.
The vitamin supplement should be taken at least 2 hours before or after the administration how to use orlistat 120mg er How to use orlistat 120mg er, such as at bedtime. For patients receiving both Xenical and cyclosporine therapy, administer cyclosporine 3 hours after Furosemide 4 link how to use orlistat 120mg er For patients receiving both Xenical and levothyroxine therapy, administer levothyroxine and Xenical at least 4 hours apart.
Patients treated concomitantly please click for source Xenical and levothyroxine should be monitored for changes in thyroid function.
Based on fecal fat measurements, the effect of Xenical is seen as soon as 24 to 48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48 to 72 hours.
Therefore, Xenical and cyclosporine should not be simultaneously coadministered. Withdrawal duration bystolic reduce the how to use orlistat 120mg er of a drug-drug interaction, cyclosporine should how to use orlistat 120mg er taken at least 3 hours before or after Xenical how to use orlistat 120mg er patients taking both drugs.
In addition, in those patients whose cyclosporine levels are being measured, more how to use orlistat 120mg er monitoring should be considered.
In addition, the levels of vitamin D and beta-carotene may be low in obese patients compared with non-obese subjects. The supplement should be taken once a day at least 2 hours before or after the administration of Xenical, such as at bedtime. A reduction in dose of oral hypoglycemic medication e. There have been rare postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure in patients treated with Xenical, with some of these cases resulting in liver transplant how to use orlistat 120mg er death.
Patients should be instructed to report any how to use orlistat 120mg er of hepatic dysfunction anorexia, pruritus, jaundice, dark urine, light-colored how to use orlistat 120mg er, or right upper quadrant pain while taking Xenical.
When these symptoms occur, Xenical and other suspect medications should be discontinued immediately how to use orlistat 120mg er liver function tests and ALT and AST levels obtained. Some patients may develop increased levels of urinary oxalate following treatment with Xenical.
Cases of oxalate how to use orlistat 120mg er and oxalate nephropathy with how to use orlistat 120mg er failure have been reported.
Monitor renal function when prescribing Xenical to patients at risk for renal impairment and use with caution in those with a history of hyperoxaluria or calcium oxalate how to use orlistat 120mg er. Substantial weight loss can increase the risk of cholelithiasis. In a clinical trial of Xenical for the prevention of type 2 diabetes, the rates of cholelithiasis as an adverse event were 2.
Organic causes of obesity e.
Patients should be advised to adhere to dietary guidelines [see Dosage and Administration 2 ]. Gastrointestinal events [see Adverse Reactions 6. The daily intake of fat should be distributed over three main meals.
If Xenical is taken with any one meal very high in fat, the possibility of gastrointestinal effects increases. Because clinical trials are conducted under widely how use conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the orlistat 120mg trials of another drug and may not reflect the rates observed in patients.
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