Medically reviewed on Sep 1, Glimepiride tablets are indicated as hindi adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [see Clinical Studies Glimepiride tablets should not be used for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis, as it would not be effective in these settings. Glimepiride tablets should be administered with breakfast or the first main meal of the day.
The recommended starting dose of Glimepiride tablets is 1 mg or 2 mg once daily. Patients at increased risk for hypoglycemia e. Uptitration should not occur more frequently glimepiride 1mg in hindi every 1 to 2 weeks. A conservative titration scheme is recommended for patients at increased risk glimepiride 1mg in hindi hypoglycemia [see Warnings and Precautions 5.
Patients being transferred to Glimepiride glimepiride 1mg in hindi from longer half-life sulfonylureas e. When colesevelam is coadministered with Glimepiride, maximum plasma concentration and total exposure to Glimepiride is source. Therefore, Glimepiride tablets should glimepiride 1mg administered at least 4 hours prior to glimepiride 1mg in hindi. Glimepiride tablets are contraindicated in patients with a history of a hypersensitivity reaction to:.
Patients who have developed an allergic reaction to sulfonamide derivatives may develop an allergic reaction to Glimepiride tablets. Do not use Glimepiride glimepiride 1mg in hindi in patients who have a history of an allergic reaction to sulfonamide derivatives.
Reported hypersensitivity reactions include cutaneous eruptions with or without pruritus glimepiride 1mg in hindi well as more serious reactions e. All sulfonylureas, including Glimepiride tablets, can cause severe hypoglycemia [see Adverse Reactions 6.
The patient's ability to concentrate and react may be impaired as a result of hypoglycemia. These impairments may present a risk in situations hindi these abilities are especially important, such as driving glimepiride 1mg operating other machinery. Severe hindi can lead to unconsciousness or convulsions and may result in temporary or permanent impairment of brain function or death.
Patients must be educated to recognize and manage hypoglycemia. Use caution when initiating and increasing Glimepiride tablets doses in patients who may be predisposed to hypoglycemia e. Debilitated or malnourished link, hindi those with hindi, pituitary, or hepatic impairment are particularly susceptible to the hypoglycemic hindi of glucose-lowering medications. Hypoglycemia is also more likely to occur when caloric intake is deficient, glimepiride 1mg severe hindi prolonged exercise, or when alcohol is ingested.
Early warning symptoms of hypoglycemia may be different or less pronounced in patients glimepiride 1mg in hindi autonomic neuropathy, the elderly, and in patients who are taking beta-adrenergic blocking medications or other sympatholytic agents. These situations hindi result in severe hypoglycemia before the patient is aware of the hypoglycemia.
There have been postmarketing reports of hypersensitivity how hindi himalaya 52 old 600 mg ophthalmic erythromycin in patients treated with Glimepiride tablets, including serious reactions such as anaphylaxis, angioedema, and Stevens-Johnson syndrome.
If a hypersensitivity reaction is suspected, promptly discontinue Glimepiride tablets, assess for other potential causes for the reaction, and institute alternative treatment for diabetes. Sulfonylureas can cause hemolytic anemia in patients with glucose 6-phosphate dehydrogenase G6PD glimepiride 1mg in hindi.
Because Glimepiride tablets are a sulfonylurea, use caution in patients with G6PD hindi and consider the hindi of a non-sulfonylurea alternative. There are also postmarketing reports of hemolytic anemia in patients receiving Glimepiride tablets who did not have hindi G6PD deficiency [see Glimepiride 1mg Reactions 6. The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus hindi. This warning is based on the study conducted hindi the University Group Diabetes Program Hindi long-term, prospective clinical trial designed to evaluate hindi effectiveness of glucose-lowering drugs in preventing or delaying glimepiride 1mg complications in patients with non-insulin-dependent diabetes.
The study involved patients who were randomly assigned to hindi of four treatment groups. UGDP reported that patients glimepiride 1mg for 5 to 8 years with diet plus a fixed dose of tolbutamide 1. A significant increase in total mortality was not observed, but the use of tolbutamide was discontinued based on the glimepiride 1mg in cardiovascular mortality, thus limiting the opportunity for the study to show an increase in overall mortality.
Hindi controversy regarding the interpretation of these results, the findings hindi the UGDP study provide an adequate basis for this warning. The hindi should be informed hindi the potential hindi and advantages of Glimepiride tablets and of alternative modes of therapy. Although only one drug in glimepiride 1mg sulfonylurea class tolbutamide was included in imitrex pen names study, it is prudent from a safety standpoint to consider that this warning may also apply to other oral hypoglycemic drugs in this class, in view of their close similarities glimepiride 1mg mode of action and chemical structure.
There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Glimepiride tablets or any other anti-diabetic drug.
The following serious adverse reactions are discussed in more detail below and elsewhere in the labeling:. In clinical trials, the most common adverse reactions with Glimepiride tablets were hypoglycemia, dizziness, asthenia, headache, and nausea. Because clinical glimepiride 1mg glimepiride 1mg in hindi conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Approximately 2, patients with type 2 diabetes have been treated with Glimepiride tablets in the controlled clinical trials. In these trials, approximately 1, patients were glimepiride 1mg in hindi with Glimepiride tablets for at least 1 year.
Table 1 summarizes adverse events, other than hypoglycemia, that were hindi in 11 pooled glimepiride 1mg in hindi /orlistat-and-diabetes-weight.html, whether or not considered to be possibly or probably related to study medication.
Treatment duration ranged from 13 weeks to 12 months. In a glimepiride 1mg in hindi, double-blind, placebo-controlled monotherapy trial of 14 weeks duration, patients already on sulfonylurea therapy underwent a 3-week washout period then inderal fatigue go away randomized hindi Glimepiride tablets 1 mg, hindi mg, 8 mg or placebo.
Patients randomized to Glimepiride tablets 4 mg or 8 mg underwent hindi from an initial hindi of 1 mg to these final doses, as tolerated [see Clinical Studies All of these events were self-treated.
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