We headache to determine the efficacy and safety of etodolac, in acute migraine attacks in comparison with paracetamol acetaminophen. Two hundred and twenty-nine adult patients having 2 to 8 attacks monthly from 17 centers were included.
The patients were instructed to use 3 attack treatment packages consisting of 1, mg paracetamol, mg etodolac, and mg etodolac on 3 migraine attacks of moderate-severe intensity each in a 3-month treatment period, interchangeably.
Any pain medication was used in 1, migraine attacks while study treatments were used in 1, attacks. The results for 1, etodolac 400 mg for pain headache paracetamol, mg for pain, and mg etodolac motrin time between doses schedule as follows: There were no statistically significant differences between the groups regarding the headache etodolac 400 mg for pain headache, pain-free, sustained pain-free, and etodolac 400 mg for pain headache etodolac 400.
Nausea, vomiting, etodolac 400 mg for pain headache, or photophobia decreased similarly in all groups within 24 hours of treatment administration. Drug-related adverse events were noted in 8 patients with 1, mg paracetamol, in 9 patients with mg etodolac and in 9 patients for mg etodolac during headache study.
Our study showed that etodolac is a safe and effective alternative in acute migraine treatment and showed comparable efficacy to paracetamol 1, mg.
Etodolac may be considered as an alternative option for acute treatment of migraine.
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