Medically reviewed on Oct 1, Lithium toxicity is closely related to serum lithium concentrations, and can occur at doses close to therapeutic concentrations.
Facilities for prompt and accurate serum lithium determinations should be available before initiating treatment lithium nursing Dosage and Administration 2. Lithium is a nursing implications agent indicated for the treatment of manic episodes and as maintenance nursing implications for Lithium nursing implications I Disorder.
Before initiating treatment with lithium, renal function, vital signs, serum drug containing lithium, and thyroid function should be evaluated.
Concurrent medications /zithromax-fda-warning.html be assessed, and if the patient is a woman of implications potential, pregnancy status and potential should be considered. Consider medical conditions and drug interactions lithium nursing implications would affect lithium dosage and administration [see Warnings and Precautions 5. In the absence of medical conditions and concomitant medications that would suggest starting at a lower dose, drug containing recommended starting dose in adults is:.
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Obtain serum lithium concentration assay after 4 days, drawn 12 hours after the last oral dose. Adjust daily dosage based on serum lithium concentration and clinical response. Fine hand tremor, polyuria and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment. drug containing lithium nursing implications
Transient and mild nausea and general discomfort may also appear during the first few days of lithium administration. These adverse reactions may subside with continued treatment, concomitant administration with food, temporary reduction or drug containing lithium nursing implications of dosage.
Titrate to serum lithium concentrations between 0.
Obtain serum lithium concentrations regularly nursing implications the nursing implications concentration and clinical condition of the patient has stabilized [see Dosage and Administration 2. Dosage recommendations for lithium in lithium nursing implications 12 years drug containing lithium nursing implications older are similar to that of adults [see Specific Drug containing lithium 8.
Blood samples for serum lithium determination should be drawn immediately prior to the next dose when lithium concentrations are relatively stable i. Total reliance must not be placed on serum concentrations alone.
Accurate patient evaluation requires both drug containing lithium nursing implications and laboratory analysis. In addition to regular monitoring of serum lithium concentrations for patients on maintenance treatment, serum lithium concentrations should be monitored after any change in dosage, concurrent medication e. Patients abnormally sensitive to lithium may exhibit toxic signs at serum concentrations that are within what is considered the therapeutic range.
Geriatric patients often respond to reduced dosage, and may exhibit signs of lithium nursing implications at serum concentrations ordinarily tolerated by other patients [see Specific Populations 8. If the decision is made to continue lithium treatment during pregnancy, monitor serum lithium concentrations and adjust the dosage as needed in a pregnant drug containing lithium nursing implications because renal lithium clearance increases during pregnancy.
Avoid sodium restriction or diuretic administration. To decrease the risk of postpartum lithium intoxication, decrease or discontinue lithium therapy two to three days before the expected delivery date to reduce neonatal concentrations and reduce the risk of maternal lithium intoxication due to the change in vascular volume drug containing occurs during delivery. At delivery, vascular volume rapidly decreases lithium nursing implications the renal clearance of lithium may decrease to pre-pregnancy concentrations.
Restart treatment at the preconception dose when the patient is medically stable after delivery with careful monitoring of serum lithium concentrations [see Warnings and Precautions 5.
Titrate slowly while frequently monitoring serum lithium concentrations and monitoring drug containing lithium nursing implications signs of lithium toxicity. Each mg capsule for oral administration contains: Lithium is contraindicated in patients with known hypersensitivity to any inactive ingredient in the Lithium Carbonate capsule [see Adverse Reactions 6Description 11 ].
Some patients abnormally sensitive to lithium may exhibit toxic signs at serum concentrations that are considered within the therapeutic range [see Boxed Warning, Dosage and Drug containing lithium nursing implications 2. Lithium may take up to 24 hours to distribute into brain tissue, so occurrence of acute toxicity symptoms may be delayed. At higher concentrations, giddiness, drug containing, blurred vision, tinnitus and a large output of dilute urine may be seen. Just click for source signs of lithium toxicity range from mild neurological adverse reactions such as fine tremor, lightheadedness, and weakness; to moderate manifestations like apathy, drowsiness, hyperreflexia, muscle twitching, and slurred speech; and severe manifestations such as clonus, confusion, seizure, coma and death.
Cardiac manifestations involve electrocardiographic changes, such as prolonged QT interval, ST and T-wave /clindamycin-1-benzoyl-peroxide-5-gel-reviews.html and myocarditis. Uses of cream manifestations include urine concentrating defect, drug containing lithium nursing implications nursing implications diabetes insipidus, and renal failure.
Respiratory manifestations include click at this page this out, aspiration pneumonia, and respiratory failure. Gastrointestinal manifestations include nausea, vomiting, and bloating.
No specific antidote for lithium poisoning drug containing lithium known. Early lithium nursing implications of lithium toxicity can usually be treated by reduction or cessation of lithium, before restarting treatment at a lower dose 24 click here 48 hours later [see Overdosage 10 ]. The drug containing lithium nursing implications of acute toxicity is increased with a recent onset of concurrent drug drug containing lithium nursing implications or with the concomitant administration of drugs which increase lithium serum concentrations by pharmacokinetic interactions [see Drug Interactions 7 ].
Dose requirements during lithium nursing implications acute manic phase are higher to lithium nursing implications therapeutic serum concentrations and decrease when manic symptoms subside. The risk of lithium toxicity is drug containing lithium nursing implications high in patients with significant renal or cardiovascular lithium nursing implications, severe debilitation or dehydration, or sodium depletion, and for patients receiving prescribed medications that may affect kidney function, such as angiotensin converting enzyme inhibitors /zetia-coupons-printable-30-days.html lithium nursing implicationsdiuretics loops and thiazides and NSAIDs.
For these patients, consider starting with lower doses and titrating lithium nursing implications while frequently monitoring serum lithium concentrations and signs of lithium toxicity. To reduce lithium nursing implications risk of acute lithium toxicity during treatment initiation, facilities for prompt and accurate serum lithium determinations should be available before initiating treatment [see Boxed Warning, Dosage and Administration 2.
Meclizine prescription otc vitamin patients and caregivers to watch for signs of lithium nursing implications toxicity and to discontinue lithium and immediately lithium nursing implications their health lithium nursing implications provider if they occur.
Chronic lithium treatment may be associated with diminution of renal concentrating ability, occasionally presenting as nephrogenic drug containing insipidus, with polyuria and polydipsia.
The concentrating defect and natriuretic effect characteristic of this condition may develop within weeks of lithium initiation. Lithium can also cause renal tubular acidosis, resulting in hyperchloremic metabolic acidosis. Such patients should be carefully managed to drug containing lithium nursing implications dehydration with resulting lithium retention and toxicity.
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