The treatment arm containing the alpha-adrenoceptor blocker doxazosin has been found to be less effective than the diuretic chlorthalidone in reducing hypertensive heart doxazosin heart failure vs heart failure. The MARC advises doxazosin heart failure until there is better definition of this issue, it may be appropriate to avoid alpha-adrenoceptors in patients with hypertension if an alternative is available.
The situation is unclear in patients with benign prostatic hypertrophy failure the use of doxazosin can result in significant improvement in symptoms and quality of life. This trial is comparing treatment of hypertension with a diuretic chlorthalidone against newer types of antihypertensives - an alpha-adrenoceptor blocker doxazosinan ACE inhibitor, and a calcium antagonist - in a high-risk patient group failure over 55 years with one or doxazosin heart failure vs heart failure cardiovascular disease CVD risk factors.
By January failure, a total of subjects had been randomised 52 philippines 100s the doxazosin treatment arm and another to receive chlorthalidone.
The failure age was 67 years and both groups had similar demographics and CVD baseline characteristics. Median follow up was 3.
At baseline there was no difference in mean blood pressure BP between the 2 groups. Failure heart other antihypertensives were added if BP wasn't controlled on maximal doses of the study medicines.
Doxazosin gave similar results to chlorthalidone for the primary endpoint of fatal coronary heart disease CHD and nonfatal myocardial infarction MIand hence did not show superior efficacy doxazosin heart failure vs heart failure the diuretic. There was no difference in all-cause mortality. The other significant finding was that doxazosin was less effective in controlling systolic BP by an average of 3mmHg.
It is important to note that the findings may apply only to high-risk patients for CVD when given doxazosin as first-line treatment for hypertension.
At year 3, over half of each group who were still taking their blinded medication, were taking the study medicines at maximal doxazosin heart. Further analysis of the data will undoubtedly follow.
This trial did doxazosin heart failure vs heart failure compare efficacy of doxazosin doxazosin heart failure vs heart failure chlorthalidone with placebo.
Hence, as stated by the study authors, "it is difficult to judge whether in ALLHAT the CHF rate with doxazosin is the same as, less than, or more than would be expected without antihypertensive drug treatment.
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