Scopolamine should be used to reduce nausea associated with motion sickness, but it does does zofran work for motion sickness reduce vomiting. Strength of Recommendation [SOR]: A, based on multiple randomized controlled trials [RCTs]. First-generation antihistamines dimenhydrinate and chlorpheniramine can also be used to reduce nausea associated with motion sickness. B, based on multiple RCTs.
Scopolamine is more effective than meclizine Antivert and as effective for motion sickness dimenhydrinate.
Ondansetron Zofran and the second-generation antihistamines cetirizine Zyrtec and fexofenadine Allegra do not reduce symptoms of motion sickness and should not be used. B, based on small RCTs.
Ginger can be used to reduce symptoms of motion sickness. B, based on RCTs with conflicting results. A Cochrane review of for motion sickness href="/plavix-25-mg-gi.html">plavix 25 mg gi RCTs with a total of 1, participants who had sea- or lab-induced motion sickness compared scopolamine for motion sickness placebo and various other agents. Patients receiving scopolamine were more likely to have dry mouth a 22 to 50 does zofran work increase. Three of the RCTs compared scopolamine with antihistamines.
Two studies found scopolamine to be superior to for motion sickness, and one found it to be equivalent to dimenhydrinate. Numerous histamine For motion sickness 1 receptor antagonists are available over the counter and by prescription, including dimenhydrinate, chlorpheniramine, diphenhydramine Benadryland meclizine.
A higher incidence of dry mouth was found does zofran work dimenhydrinate, and more sedation was reported with chlorpheniramine. Click the following article various delivery methods 1.
Chlorpheniramine 4 mg and 12 mg 3. Cetirizine Zyrtecfexofenadine Allegra 4. Ginger 1 g powdered root 7.
Ginger 1- or 2-g capsules 8. Ginger mg powdered root 9.
Ginger to 1, mg powdered or does zofran does zofran work for motion sickness root Information from for motion sickness 1 through One RCT does zofran work for motion sickness 18 healthy participants evaluated the second-generation, nonsedating antihistamines cetirizine and fexofenadine in lab-induced motion sickness, and found no statistically significant difference in motion sickness scores compared with placebo.
Two well-designed RCTs that included a total of 86 participants with sea- or lab-induced motion sickness found that ondansetron did not reduce motion sickness symptoms compared with placebo. Two higher-quality, placebo-controlled RCTs found that ginger reduced vomiting but not nausea in the larger trial, and delayed the onset and for motion sickness the intensity of nausea in the smaller trial.
Based on a summary of the evidence and expert opinion, UpToDate recommends the use of sedating antihistamines, scopolamine, or ginger for the treatment of motion sickness. Already a link or subscriber? Address correspondence to Matthew Sutton, MD, at msutton unch.
Reprints does zofran work for motion sickness not available from the allergic reaction zoloft. Spinks A, Wasiak J. Scopolamine hyoscine for preventing and treating motion sickness Cochrane Database Syst Rev. Transdermally administered scopolamine vs. Effect on nausea and for motion sickness in experimentally induced motion sickness. Chlorpheniramine for motion sickness. Failure of cetirizine and fexofenadine to prevent motion sickness.
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