Diltiazem topical treatment
Treatment anal fissure has traditionally been treated surgically.
Initial enthusiasm for chemical diltiazem topical treatment has waned diltiazem topical treatment of poor outcomes with glyceryl trinitrate treatment. In this study the use of topical 2 per cent diltiazem ointment has been investigated as an alternative method of chemical sphincterotomy.
A prospective assessment of 71 consecutive patients with a chronic anal fissure treated with 2 per cent topical diltiazem ointment for a median duration of 9 range weeks was performed.
Fifty-one patients 75 per cent experienced healing of the fissure after months of treatment with topical diltiazem. Seventeen patients who did not heal were treated for a further 8 weeks diltiazem topical treatment topical diltiazem. Eight of these patients subsequently healed with diltiazem.
Topical diltiazem ointment in the treatment of chronic anal fissure.
Fifty-nine of 67 patients who completed follow-up therefore healed on diltiazem ointment. Four patients experienced perianal dermatitis diltiazem topical treatment one patient experienced headaches.
No other side-effects were recorded.
After a median of 32 range weeks' follow-up following completion of treatment, 27 of 41 patients diltiazem topical treatment remain symptom free. Six of seven patients with recurrent fissure were treated successfully by repeat chemical sphincterotomy.
Topical 2 treatment cent diltiazem topical treatment ointment diltiazem topical as an agent for chemical sphincterotomy for chronic anal fissure offers significant healing rates but does not have a significant side-effect profile, which may aid compliance to treatment. Early recurrences are treatment but usually amenable to further chemical sphincterotomy.
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The content of this evidence summary was up-to-date in January Diltiazem hydrochloride is a calcium channel blocker and vasodilator.
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The treatment of anal fissures has evolved over the last 5 years with the development of topical treatments aimed at reducing sphincter hypertonia. This is thought to improve anal mucosal blood flow and promote healing of the fissure.
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In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment.
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