Use lowest effective dose for shortest duration.
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Increased risk of serious GI adverse events including inflammation, bleeding, ulceration, perforation. Hypertension; monitor BP closely. Hepatic or renal impairment.
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Potentiates digoxin; monitor levels.
May potentiate lithium, methotrexate, cyclosporine; monitor for toxicity. Concomitant with pemetrexed may increase risk of pemetrexed-associated myelosuppression, renal, click here GI toxicity.
Caution with other hepatotoxic drugs eg, acetaminophen, certain antibiotics, antiepileptics. Compare To Related Drugs.
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