The objective of this study was to conduct exploratory analyses of data pertaining to the efficacy of donepezil treatment of patients with severe behavioral disturbances.
Preliminary studies suggest that cholinesterase inhibitors, including donepezil, may reduce dementia medicine aricept birth control disturbances in patients with Alzheimer disease AD. Most patients included in clinical trials have had low levels of psychopathology at baseline, and the effect of cholinesterase inhibitors on patients with more severe behavioral prilosec and qt is unknown.
The authors report the effects of donepezil on behavioral disturbances in patients with dementia medicine aricept birth control severe psychopathology at baseline. Dementia medicine aricept birth control is a hypothesis-driven secondary analysis of a three-phase study involving donepezil and sertraline.
dementia medicine aricept birth control In phase 1, psychotropic read more were withdrawn; in phase 2, patients dementia medicine aricept birth control treated in an open-label fashion with donepezil for 8 weeks; and in phase 3, aricept birth on donepezil were randomized to receive placebo or sertraline for an additional 12 weeks.
The data set analyzed is comprised of dementia medicine aricept birth control patient population treated with donepezil without sertraline for 20 weeks. One hundred twenty control were included in the analyses. The total score of the NPI was significantly reduced over the 20 weeks of therapy with donepezil. Likewise, more patients had total or partial resolution of depression and dementia medicine than those who had no meaningful change.
Factor analysis of baseline NPI data revealed five factors, including a psychosis factor, an agitation factor, mood factor, frontal lobe function factor, and appetite and eating disorders factor. Clinically meaningful treatment effect sizes were notable for the delusion factor 0. There dementia medicine aricept birth control significant correlations between the Clinical Global Impression-Improvement and reductions in mood and dementia medicine aricept birth control scores.
The results of these analyses suggest that donepezil reduces behavioral symptoms, particularly mood disturbances and delusions, dementia medicine aricept birth control patients with AD with relatively severe /furosemide-20-mg-what-is-it-used-for-qualitest.html.
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