Essential tremor ET is one of the most common movement disorders. The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy.
For these reasons, it topamax essential tremor worthwhile evaluating other treatments for ET. Topiramate has been suggested as a potentially useful agent for the treatment of ET but there is uncertainty about its efficacy and safety. To assess the efficacy and safety classification of topamax essential tremor topiramate in the treatment of ET. We handsearched grey literature and the reference lists of identified go here classification reviews.
We included studies in which the diagnosis of ET was made according to accepted and validated diagnostic criteria. We excluded studies conducted in people presenting with secondary forms of tremor classification of topamax essential tremor reporting only neurophysiological parameters to assess outcomes. Two review authors independently collected and extracted data using a data collection form.
We assessed the risk of bias and the quality of evidence. Essential tremor used a fixed-effect meta-analysis for data synthesis.
This review included three trials comparing topiramate to placebo participants. They were all at high overall risk of bias.
The quality of evidence ranged from very low to low. Compared to placebo, participants treated with more info showed a significant improvement in functional disability and an increased risk of withdrawal risk ratio Classification topamax 1.
There were more AEs for topiramate-treated participants, particularly paraesthesia, weight loss, appetite decrease classification classification of topamax essential tremor topamax essential tremor memory difficulty. This systematic review highlighted the presence of limited data classification read more topamax essential tremor very low to low quality evidence to support the apparent efficacy and the occurrence of treatment-limiting AEs in people with ET treated with topiramate.
Further research to assess topiramate efficacy and safety on ET is needed.
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