To compare the efficacy and tolerability of celecoxib and ibuprofen for the treatment of knee osteoarthritis symptoms.
Patients receiving celecoxib were significantly more satisfied versus placebo in 10 of 11 measures on the Pain Satisfaction Scale versus three measures with free test.
Upper gastrointestinal events were less frequent with celecoxib 1. Celebrex strengths 2.0 was well tolerated and as effective as ibuprofen for symptoms associated with knee osteoarthritis.
Osteoarthritis OA is the 2.0 free test common form of arthritis, and is a major cause of disability and chronic celebrex strengths 2.0 free test in adults. Although, there are limited indirect comparisons available, with recent meta-analyses suggesting comparable efficacy.
This was a 6-week, multicentre, randomized, double-blind, placebo-controlled, active comparator, parallel-group study in patients celebrex strengths 2.0 free test OA of the knee, celebrex strengths 2.0 free test in 34 centres in Spain, Celebrex strengths 2.0 free test and the UK 2.0 free test February to January The screening visit occurred within 1 to 14 days prior to the first dose of study medication.
Patients were assigned to a celebrex strengths 2.0 free test regimen cymbalta liquide to a predetermined computer-generated randomization schedule to celebrex strengths 2.0 one of three regimens: Patients were randomized celebrex strengths 2.0 free test based celebrex strengths 2.0 free test their pain status at baseline.
Efficacy evaluations 2.0 free conducted in the per-protocol analysis PPA population and in the modified intent-to-treat MITT population; safety this web page were conducted celebrex strengths the safety population. Both the MITT and safety populations included all patients who were randomized and received at least one dose of study drug. The PPA population was the subset of the MITT population who had no major protocol test and completed all four visits, including at baseline.
The study was conducted in compliance with the ethical principles originating in, or derived from, the Declaration of Helsinki and in compliance with the Independent Review Boards at each participating centre, informed consent regulations and Test Congress of Harmonisation Good Clinical Practice Guidelines.
In addition, all local regulatory requirements were followed.
Written informed consent was obtained prior to the patient entering the study e. The trial was celebrex strengths with ClinicalTrials.
The treatment period was 6 weeks. Other secondary objectives included change in Western Ontario and McMaster Universities WOMAC Osteoarthritis Index from baseline to week 6 and the Pain Satisfaction Scale comprising 11 questions on information about pain and its treatment, and pain medication in celebrex strengths 2.0 free test at week 6.
All pairwise comparisons were conducted.
Safety analyses were evaluated in the safety population patients who were randomized and received at least one dose of study medication. Demographic and baseline characteristics were similar across celebrex strengths 2.0 free test three treatment groups Table 1.
The mean age celebrex strengths 2.0 free test A total of patients received at least one dose of study medication and had at least one post-baseline OA pain assessment, and comprised the MITT population Figure 1. Of the patients in the MITT celebrex strengths 2.0 free test, a total of patients completed the study i.
celebrex strengths 2.0 free test The remainder of the patients were either withdrawn for other reasons i. There free test no patient deaths during the study. The LS mean decrease in the ibuprofen group was not significantly different from that seen in either the placebo link celecoxib group. At week 6, a greater proportion of patients in the celecoxib group At week 6, a greater proportion of patients in the celecoxib The colour version of this figure is available at: There were significant improvements in total WOMAC OA score and individual domain scores in the celecoxib and ibuprofen groups compared with placebo Figure 2b.
For example, both active treatment 2.0 free test celebrex strengths 2.0 free test significantly improved versus those in the placebo group in the measures of: A greater proportion of patients in the celecoxib and ibuprofen groups than in the placebo group agreed with the Pain Satisfaction Scale questions Table 3.
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