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Here we present a series of case reports. Table 1 provides a summary of these cases.
Case 1 is a yr-old man with a history of intractable left lower-extremity pain after a war-related injury that necessitated a below-knee amputation. He described his pain as a constant burning sensation over the stump with paroxysms of lancinating pain radiating from the can you inject baclofen 10 mg dl portion of the stump to the knee and thigh.
The intensity was rated at a 10 using a 0—10 verbal pain scale. The patient was treated more info several years with oral opioids, antidepressants, anticonvulsants, phenothi-azines, muscle relaxants, peripheral nerve blocks, and a transcutaneous electric nerve stimulator.
He also had a revision of the amputation and surgical neurolysis of the peroneal nerve. However, the reexploration only worsened the burning pain in the stump.
The patient was referred to the pain clinic as a last option before proceeding with an above-the-knee amputation. After the can you inject baclofen 10 mg dl of an intrathecal catheter and a Medronic Synchromed infusion pump Minneapolis, MNthe patient required increasing doses of intrathecal morphine to maintain the initial can you inject baclofen 10 mg dl.
The addition of bupivacaine to the infusion helped to control his pain for 1. At these doses, the patient developed side effects that included sedation, peripheral edema, and shortness of breath. Within days his neuropathic pain improved, and the need for morphine decreased, allowing the eventual discontinuation of the morphine in the pump.
In addition, he was better able to perform his activities of daily living, his sleep pattern improved, and his physical activity increased.
His motor baclofen and deep tendon reflexes were unchanged since initiation of baclofen therapy. His pain was absent with activity and ranged from 0 to 6 at rest. The rest pain was fairly well controlled with oral gabapentin mg three times per day.
The more severe lancinating paroxysmal episodes of pain had completely resolved. Case 2 is a yr-old woman referred for the treatment of intractable low back can you inject and neuropathic pain of the lower extremities after multiple lumbar laminectomies and fusions with bone grafts. Treatment with physical therapy, can you inject baclofen 10 can you dl electric nerve stimulator, and tricyclic antidepressants had provided inadequate pain relief.
High-dose oral opioids provided inadequate analgesia and intolerable side effects. She rated her pain as 9—10 on a 0—10 verbal pain scale. The patient reported marked improvement of the low back pain but only minimal improvement of the radicular burning pain. Bupivacaine was added can you inject baclofen 10 mg dl the inject baclofen, and the infusion was slowly increased to 6.
The pain stabilized at these doses at a level of 4—7 of link can you inject baclofen 10 mg dl However, she developed fluid retention, shortness of breath, peripheral edema, and sedation. An attempt baclofen lower the infusion rate was associated with exacerbation of the inject baclofen. During the first day of baclofen therapy, her pain decreased from 7 inject baclofen 4 of a possible 10, and her side effects slowly improved over the following week.
There was no subjective weakness noted by the patient, and her motor examination and reflexes were unchanged from her initial examination. Her activities of daily living were not improved because of other unrelated can you inject baclofen 10 mg dl problems. She reported no side effects to the intrathecal infusion. Case 3 is a yr-old man with cerebral palsy and a article source of intractable low back pain and burning radicular pain in the left lower extremity, unrelieved by a lumbar laminectomy and fusion.
Motor function and reflexes can you inject baclofen 10 mg dl the lower extremities were intact.
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