We determined whether clomipramine taken as needed increases ejaculation latency in men with premature ejaculation and controls.
The study anafranil 20 mg 75 8 patients with primary premature ejaculation, 6 with premature ejaculation and erectile dysfunction, and 8 controls.
A prospective, double-blind, placebo controlled, crossover continue reading was used that included anafranil 20 mg 75, 3-week periods with clomipramine anafranil 20 mg 75 placebo. During treatment phases subjects took either 25 mg.
Subjects also visited the laboratory during these phases for evaluation of sexual response using visual erotic stimulation with and without anafranil to the penis. Daily logs of sexual activities were maintained during treatment phases.
Clomipramine significantly increased the latency to ejaculation during sexual activity coitus or masturbation from approximately 2 to 8 minutes in men with primary premature ejaculation. There were no significant effects in controls and men anafranil premature ejaculation plus erectile dysfunction.
Laboratory assessment indicated that men with primary premature ejaculation were better able to control ejaculatory response with clomipramine therapy. In these men clomipramine also anafranil 20 mg anafranil in increased satisfaction with sex life and relationship. Clomipramine inhibited nocturnal penile tumescence in all anafranil 20 mg 75.
Clomipramine oral capsule is available as the brand-name drug Anafranil. Generic drugs usually cost less than the brand-name version.
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